Mutation Information
Mutation Site
|
I84V |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
PR |
Genotype/Subtype
|
B |
Relevant Drug
|
atazanavir (ATV);darunavir (DRV);fosamprenavir (FPV);indinavir (IDV);lopinavir (LPV);nelfinavir (NFV);saquinavir (SQV);tipranavir (TPV) |
Literature Information
PubMed PMID
|
30560871
|
Published Year
|
2018 |
Journal
|
Scientific reports |
Title
|
Characterizing early drug resistance-related events using geometric ensembles from HIV protease dynamics. |
Author
|
Sheik Amamuddy O,Bishop NT,Tastan Bishop Ö |
Evidence
|
Additional research on multi-drug resistant HIV protease further described an expanded active site pocket and cavity expansion due to atomic volume for the HIV protease mutants V82A and I84V.
|
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