|
Mutation Information
|
Mutation Site
|
I84V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
Literature Information
|
PubMed PMID
|
18597780
|
|
Published Year
|
2008 |
|
Journal
|
Journal of molecular biology |
|
Title
|
Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. |
|
Author
|
Liu F,Kovalevsky AY,Tie Y,Ghosh AK,Harrison RW,Weber IT |
|
Evidence
|
The 80's loop shows intrinsic flexibility as described previously for atomic resolution structures of saquinavir complexes with wild type PR and mutants V82A and I84V and a 9X mutant with indinavir.
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|
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HIV Mutation Detail Information