|
Mutation Information
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Mutation Site
|
I74A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpr |
Literature Information
|
PubMed PMID
|
17140287
|
|
Published Year
|
2006 |
|
Journal
|
PLoS pathogens |
|
Title
|
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT. |
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Author
|
Andersen JL,DeHart JL,Zimmerman ES,Ardon O,Kim B,Jacquot G,Benichou S,Planelles V |
|
Evidence
|
Certain mutants of Vpr, such as R77Q and I74A, identified in long-term nonprogressors, have been proposed to inefficiently induce apoptosis while activating the G2 checkpoint in a normal manner.
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HIV Mutation Detail Information