|
Mutation Information
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Mutation Site
|
I72V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
darunavir (DRV) |
Literature Information
|
PubMed PMID
|
27992544
|
|
Published Year
|
2016 |
|
Journal
|
PloS one |
|
Title
|
Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
|
Author
|
Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
|
Evidence
|
The displacement induced by A71V mutation in PRS17 affects adjacent residues His69 and I72V since the Calpha atoms of these residues have shifted by more than 1 A compared with the positions in PR/DRV.
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HIV Mutation Detail Information