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Mutation Information

Mutation Site	I70S
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vpr

Literature Information

PubMed PMID	18445273
Published Year	2008
Journal	Biology direct
Title	14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr.
Author	Bolton DL,Barnitz RA,Sakai K,Lenardo MJ
Evidence	By contrast, both wild-type Vpr and the point mutant, I70S, which does not affect G2,M-blocking function [34] (Fig. (Fig.3B,3B, top row), increased the complex of Cdk1, CyclinB1, as well as Plk1, with 14-3-3 θ. Western blots showed that similar amounts of mutant and wild-type Vpr protein were delivered (Fig. (Fig.3A,3A, input).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation