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Mutation Information
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Mutation Site
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I68T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
S |
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Combined Mutation
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s.C69*+s.I68T;s.C69*+s.I68T+s.F8L;s.C69*+s.I68T+s.G50D;s.C69L+s.I68T;s.C69*+s.I68T+s.N3S;s.I68T+s.P46T+s.S45T;s.I68T+s.P46T+s.S45T+s.N3S;s.I68T+s.P46T+s.S45T+s.F8L |
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Viral Reference
|
AY741797.1
|
|
Country
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Germany |
Literature Information
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PubMed PMID
|
28392234
|
|
Disease
|
HBV infection
|
|
Published Year
|
2017 |
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Journal
|
Journal of hepatology |
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Title
|
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy. |
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Author
|
Shirvani-Dastgerdi E,Winer BY,Celià-Terrassa T,Kang Y,Tabernero D,Yagmur E,Rodríguez-Frías F,Gregori J,Luedde T,Trautwein C,Ploss A,Tacke F |
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Evidence
|
By linkage analysis, the stop codon in the S-open reading frame (S-ORF) was always linked to sI68T, which is a silent mutation in polymerase-ORF (Table 1).
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HBV Mutation Detail Information