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Mutation Information
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Mutation Site
|
I68T |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
S |
|
Amino acid_Mutation
|
T357C |
|
Genotype/Subtype
|
C |
|
Country
|
Japan |
Literature Information
|
PubMed PMID
|
17888035
|
|
Disease
|
Chronic hepatitis B;
Hepatocellular carcinoma
|
|
Published Year
|
2007 |
|
Journal
|
Cancer science |
|
Title
|
Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma. |
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Author
|
Zhang KY,Imazeki F,Fukai K,Arai M,Kanda T,Mikata R,Yokosuka O |
|
Evidence
|
Furthermore, comparison of the frequency of mutations in the HCC group with that in the non‐HCC group at the beginning of follow‐up showed the following changes more frequent in the HCC group besides the above mentioned G1317A, T1341C/A/G (Table 7); G1764A with change of V to I at codon 131 in the X region (21/23 vs 11/20, P = 0.01), C2288A/G with changes of P to T/A at codon 130 in the core region (9/23 vs 2/20, P = 0.04), and T357C with a change of I to T at codon 68 in the S region (6/23 vs 0/20, P = 0.02) (Table 7).
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HBV Mutation Detail Information