|
Mutation Information
|
Mutation Site
|
I63K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Vpr |
Literature Information
|
PubMed PMID
|
15312229
|
|
Published Year
|
2004 |
|
Journal
|
Retrovirology |
|
Title
|
Analysis of HIV-1 Vpr determinants responsible for cell growth arrest in Saccharomyces cerevisiae. |
|
Author
|
Yao XJ,Rougeau N,Duisit G,Lemay J,Cohen EA |
|
Evidence
|
The R62P and I63K mutations introduced in the third helix were aimed at interfering with the integrity of the alpha-helix and are known to abolish Vpr nuclear localization.
|
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HIV Mutation Detail Information