|
Mutation Information
|
Mutation Site
|
I62V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
darunavir (DRV) |
Literature Information
|
PubMed PMID
|
27992544
|
|
Published Year
|
2016 |
|
Journal
|
PloS one |
|
Title
|
Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
|
Author
|
Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
|
Evidence
|
Also, I62V mutation in PRS17 results in loss of van der Waals contact with Pro39 further altering the hinge loop in comparison to PR/DRV.
|
|
|
HIV Mutation Detail Information