HIV Mutation Detail Information

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Mutation Information

Mutation Site	I54V
Mutation Type	Amino acid level
Gene/Protein/Region Type	PR

Literature Information

PubMed PMID	33314454
Published Year	2021
Journal	Protein science : a publication of the Protein Society
Title	A synergy of activity, stability, and inhibitor-interaction of HIV-1 protease mutants evolved under drug-pressure.
Author	Khan SN,Persons JD,Guerrero M,Ilina TV,Oda M,Ishima R
Evidence	A clinically-relevant, drug-resistant mutant of HIV-1 protease (PR), termed Flap+(I54V) and containing L10I, G48V, I54V and V82A mutations, is known to produce significant changes in the entropy and enthalpy balance of drug-PR interactions, compared to wild-type PR.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation