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Mutation Information
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Mutation Site
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I54V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
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abacavir (ABC);stavudine (D4T);didanosine (DDI);emtricitabine (FTC);emtricitabine (FTC);lamivudine (LAM);tenofovir (TDF);efavirenz (EFV);etravirine(ETR);nevirapine (NPV);rilpivirine (RPV);atazanavir (ATV);darunavir (DRV);fosamprenavir (FPV);indinavir (IDV);lopinavir (LPV);nelfinavir (NFV);saquinavir (SQV);tipranavir (TPV) |
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Country
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India |
Literature Information
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PubMed PMID
|
30315192
|
|
Disease
|
HIV infection/AIDS
|
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Published Year
|
2018 |
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Journal
|
Scientific reports |
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Title
|
Antiretroviral resistance, genotypic characterization and origin of Human Immunodeficiency Virus among the infected wives of Intravenous drug users in Manipur. |
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Author
|
Sharma AL,Singh TR,Singh LS |
|
Evidence
|
One sample, Manipur017 harbored multiple mutations in NRTIs (K65R, M184V), NNRTIs (Y188L) and PIs (I54V, L76V and I84V) which conferred high-level resistance to abacavir (ABC), didanosine (DDI), emtricitabine (FTC), lamivudine (3TC), and intermediate-level resistance to stavudine (d4T), tenofovir (TDF), high or intermediate level resistance to all NNRTIs and PIs (Table 3).
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HIV Mutation Detail Information