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Mutation Information
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Mutation Site
|
I54V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
Literature Information
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PubMed PMID
|
27039930
|
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Published Year
|
2016 |
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Journal
|
Biochemistry |
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Title
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Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme. |
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Author
|
Park JH,Sayer JM,Aniana A,Yu X,Weber IT,Harrison RW,Louis JM |
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Evidence
|
Unlike mutations V82S, proximal to the active site pocket, and G48V and I54V in the flap regions, non-active site mutations L90M and A71V may indirectly influence inhibitor or substrate binding.
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HIV Mutation Detail Information