|
Mutation Information
|
Mutation Site
|
I54M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
Literature Information
|
PubMed PMID
|
32309558
|
|
Published Year
|
2014 |
|
Journal
|
Discoveries (Craiova, Romania) |
|
Title
|
The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics. |
|
Author
|
Chordia P,Dewdney TG,Keusch B,Kuiper BD,Ross K,Kovari IA,MacArthur R,Salimnia H,Kovari LC |
|
Evidence
|
We identify a novel structural role for the I47V, V32I, I54M and L90M major resistance mutations in flap opening and closure of MDR-PR isolates.
|
|
|
HIV Mutation Detail Information