HIV Mutation Detail Information

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Mutation Information
Mutation Site I54M
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Relevant Drug nelfinavir (NFV)
Country Taiwan(China)
Literature Information
PubMed PMID 28107423
Clinical information Yes
Disease HIV infection/AIDS
Published Year 2017
Journal PloS one
Title Characterization of the Drug Resistance Profiles of Patients Infected with CRF07_BC Using Phenotypic Assay and Ultra-Deep Pyrosequencing.
Author Huang SW,Li WY,Wang WH,Lin YT,Chou CH,Chen M,Huang HD,Chen YH,Lu PL,Wang SF,Oka S,Chen YA
Evidence For NFV, the following mutations had positive correlation with phenotypic PI DR: D30N + G73S (R = 0.85, p = 0.01), I54T + A71V (R = 0.85, p = 0.01), I54M + M36I + L63P + I93L (R = 0.85, p< 0.01), I54L + M36V (R = 0.91, p< 0.01) and V82F + M36I + L63P + I93L (R = 0.99, p< 0.01).

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation