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Mutation Information
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Mutation Site
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I54M |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
Literature Information
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PubMed PMID
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18597780
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Published Year
|
2008 |
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Journal
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Journal of molecular biology |
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Title
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Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. |
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Author
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Liu F,Kovalevsky AY,Tie Y,Ghosh AK,Harrison RW,Weber IT |
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Evidence
|
The crystal structures of flap mutants PRI50V, PRI54V, and PRI54M complexed with saquinavir (SQV) and PRG48V, PRI54V, and PRI54M complexed with darunavir (DRV) were determined at the resolutions of 1.05–1.40 Å.
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HIV Mutation Detail Information