HIV Mutation Detail Information

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Mutation Information
Mutation Site I54M
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Relevant Drug saquinavir (SQV);lopinavir (LPV)
Literature Information
PubMed PMID 16956392
Published Year 2006
Journal Retrovirology
Title HIV-2 Protease resistance defined in yeast cells.
Author M'Barek NB,Audoly G,Raoult D,Gluschankof P
Evidence When this HIV-2ROD Protease harbours amino acid substitutions known to be involved in HIV-2 PI resistance such as K45R, I54M, or M76V, cell growth, in spite of the presence of the inhibitors, was strongly arrested achieving in some cases only 4% of normal growth (Table 1) demonstrating a tight correlation between resistance, defined in physiological conditions, and loss of susceptibility, defined in our experimental system.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation