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Mutation Information
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Mutation Site
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I54L |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
|
A1;B;URF |
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Relevant Drug
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PIs |
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Country
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German |
Literature Information
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PubMed PMID
|
30650082
|
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Disease
|
HIV infection/AIDS
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Published Year
|
2019 |
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Journal
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PloS one |
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Title
|
Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort. |
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Author
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Machnowska P,Meixenberger K,Schmidt D,Jessen H,Hillenbrand H,Gunsenheimer-Bartmeyer B,Hamouda O,Kücherer C,Bannert N,German HIV-1 Seroconverter Study Group. |
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Evidence
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In total, TDRMs at 46 positions in PR and RT were analysed. For a number of TDRMs, no loss could be observed during the observation period (S1 Table) and, according to their maximal duration of observation, the following TDRMs seem to survive for lengthy periods in the absence of ART: the NRTI resistance mutations D67N (5.9 years), K70R (6.9 years), F77L (10.2 years), T215E (5.9 years) and K219Q (5.9 years), the NNRTI resistance mutations A98G (6.5 years) and Y188L (5.9 years) as well as the PI mutations I54L (5.9 years) and L90M (8.4 years) (S1 Table).
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HIV Mutation Detail Information