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Mutation Information
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Mutation Site
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I54L |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
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nelfinavir (NFV) |
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Country
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Taiwan(China) |
Literature Information
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PubMed PMID
|
28107423
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Clinical information
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Yes
|
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Disease
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HIV infection/AIDS
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Published Year
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2017 |
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Journal
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PloS one |
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Title
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Characterization of the Drug Resistance Profiles of Patients Infected with CRF07_BC Using Phenotypic Assay and Ultra-Deep Pyrosequencing. |
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Author
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Huang SW,Li WY,Wang WH,Lin YT,Chou CH,Chen M,Huang HD,Chen YH,Lu PL,Wang SF,Oka S,Chen YA |
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Evidence
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For NFV, the following mutations had positive correlation with phenotypic PI DR: D30N + G73S (R = 0.85, p = 0.01), I54T + A71V (R = 0.85, p = 0.01), I54M + M36I + L63P + I93L (R = 0.85, p< 0.01), I54L + M36V (R = 0.91, p< 0.01) and V82F + M36I + L63P + I93L (R = 0.99, p< 0.01).
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HIV Mutation Detail Information