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Mutation Information
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Mutation Site
|
I54L |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
|
darunavir (DRV) |
Literature Information
|
PubMed PMID
|
27992544
|
|
Published Year
|
2016 |
|
Journal
|
PloS one |
|
Title
|
Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
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Author
|
Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
|
Evidence
|
PRS17 has none of the major mutations (I47V, I50V, I54ML, L76V and I84V) associated with darunavir resistance, but has 10,000-fold weaker binding affinity relative to the wild type PR.
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HIV Mutation Detail Information