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Mutation Information
|
Mutation Site
|
I50L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
PIs |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
31574109
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
PloS one |
|
Title
|
Major drug resistance mutations to HIV-1 protease inhibitors (PI) among patients exposed to PI class failing antiretroviral therapy in São Paulo State, Brazil. |
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Author
|
Soldi GFR,Ribeiro IC,Ahagon CM,Coelho LPO,Cabral GB,Lopes GISL,Ferreira JLP,Brígido LFM,Salvage Therapy Working Group. |
|
Evidence
|
Considering the specific I50L mutations to ATV, the proportion is not statistically different in HIV-1 C sequences (6.9%, 6/87 vs. B 4.4%, 76/1216, p = 0.27) overall as well as among cases with documented exposure to atazanavir (12.5%, 3/24 vs. 8.6%, 26/302, p = 0.77).
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HIV Mutation Detail Information