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Mutation Information
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Mutation Site
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I47V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
Literature Information
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PubMed PMID
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32478251
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Published Year
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2020 |
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Journal
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ACS omega |
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Title
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Visualizing Tetrahedral Oxyanion Bound in HIV-1 Protease Using Neutrons: Implications for the Catalytic Mechanism and Drug Design. |
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Author
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Kumar M,Mandal K,Blakeley MP,Wymore T,Kent SBH,Louis JM,Das A,Kovalevsky A |
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Evidence
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To obtain the complex with KVS-1TI we chose an HIV-1 PR triple mutant variant (PRTM), which contains three substitutions V32I, I47V, and V82I associated with drug resistance (Table S1), because of its demonstrated success to afford neutron diffraction quality crystals and because the resistance mutations do not introduce considerable distortions in ligand binding compared to the wild-type enzyme.
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HIV Mutation Detail Information