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Mutation Information
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Mutation Site
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I47V |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
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atazanavir (ATV);darunavir (DRV);indinavir (IDV);lopinavir (LPV);nelfinavir (NFV);saquinavir (SQV);tipranavir (TPV) |
Literature Information
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PubMed PMID
|
28155724
|
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Published Year
|
2016 |
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Journal
|
BMC bioinformatics |
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Title
|
Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance. |
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Author
|
Su CT,Ling WL,Lua WH,Haw YX,Gan SK |
|
Evidence
|
Of these mutations, residue substitutions at the flap regions I47V (in all PI resistance), I50V (in DRV and LPV), and the mutation L76V (in DRV and LPV) significantly increased the regional entropy.
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HIV Mutation Detail Information