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Mutation Information
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Mutation Site
|
I43V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Vpu |
|
Viral Reference
|
NL4.3
|
|
Immune Escape
|
Y |
|
Country
|
Canada;South Africa;Canada;Uganda;Africa;US |
Literature Information
|
PubMed PMID
|
32376625
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
|
Journal
|
Journal of virology |
|
Title
|
Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes. |
|
Author
|
Umviligihozo G,Cobarrubias KD,Chandrarathna S,Jin SW,Reddy N,Byakwaga H,Muzoora C,Bwana MB,Lee GQ,Hunt PW,Martin JN,Brumme CJ,Bangsberg DR,Karita E,Allen S,Hunter E,Ndung'u T,Brumme ZL,Brockman MA |
|
Evidence
|
Consistent with our expectations, all six substitutions significantly reduced CD4 downregulation function: V13L by -0.13, V13T by -0.3, V26T by -0.10, L34V by -0.28, I43V by -0.4, and G72E by -0.16 (all P < 0.05)(Fig. 6B).
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HIV Mutation Detail Information