|
Mutation Information
|
Mutation Site
|
I437V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gag |
|
Relevant Drug
|
PIs |
Literature Information
|
PubMed PMID
|
19300491
|
|
Published Year
|
2009 |
|
Journal
|
PLoS pathogens |
|
Title
|
Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss. |
|
Author
|
Dam E,Quercia R,Glass B,Descamps D,Launay O,Duval X,Kräusslich HG,Hance AJ,Clavel F,ANRS 109 Study Group. |
|
Evidence
|
The effect of Gag on resistance depended on the presence of cleavage site mutations A431V or I437V in NC-SP2-p6 and correlated with processing of the NC/SP2 cleavage site.
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HIV Mutation Detail Information