Mutation Information
Mutation Site
|
I424A |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
Env |
Viral Reference
|
K03455.1
|
Literature Information
PubMed PMID
|
33785631
|
Published Year
|
2021 |
Journal
|
mBio |
Title
|
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State. |
Author
|
Zhang P,Kwon AL,Guzzo C,Liu Q,Schmeisser H,Miao H,Lin Y,Cimbro R,Huang J,Connors M,Schmidt SD,Dolan MA,Armstrong AA,Lusso P |
Evidence
|
Residue I424 is part of the contact surface for sCD4 (PDB ID: 1G9N) and F105 (PDB ID: 3HI1), which may explain the only limited increase in sCD4 sensitivity of mutant I424A, while the effect on F105 sensitivity was nevertheless remarkable.
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