HIV Mutation Detail Information

> I371A Search Result

Mutation Information

Mutation Site	I371A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120

Literature Information

PubMed PMID	23011758
Published Year	2013
Journal	Proteins
Title	HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism.
Author	Tuzer F,Madani N,Kamanna K,Zentner I,LaLonde J,Holmes A,Upton E,Rajagopal S,McFadden K,Contarino M,Sodroski J,Chaiken I
Evidence	Although I371A had a moderate effect (about 10-fold compared to WT) and V101A and R480A had smaller effects (less than 2-fold and 5-fold, respectively) on CD4 or 17b inhibition by the PTs, these effects were small and as there was no prior study to validate the importance of these mutations, these mutants were not carried over to the next phase of screening.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation