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Mutation Information
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Mutation Site
|
I34L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
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Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
NC_001526
|
|
Country
|
China |
Literature Information
|
PubMed PMID
|
31670402
|
|
Disease
|
Cervical intraepithelial neoplasia
|
|
Published Year
|
2020 |
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Journal
|
Journal of medical virology |
|
Title
|
Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women. |
|
Author
|
Zhao J,Zhu J,Guo J,Zhu T,Zhong J,Liu M,Ruan Y,Liao S,Li F |
|
Evidence
|
Amino acid substitutions (D32N/E, E36Q, H85Y, and E120D in E6 and N29H/S and R77C in E7) were predicted to have an effect on conserved structural and functional residues, and five amino acid substitutions (H85Y, E36Q, I34L, and D32E in E6; R77C in E7) would potentially change the secondary structure.
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HPV Mutation Detail Information