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Mutation Information
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Mutation Site
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I33L |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
PR |
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Relevant Drug
|
darunavir (DRV) |
Literature Information
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PubMed PMID
|
27992544
|
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Published Year
|
2016 |
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Journal
|
PloS one |
|
Title
|
Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. |
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Author
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Agniswamy J,Louis JM,Roche J,Harrison RW,Weber IT |
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Evidence
|
In addition, the adjacent Met36 side chain interacts with Ile15 and Ile33 in wild-type structures, but the M36I mutation in PRS17/DRV alters the main chain (Calpha RMSD of 2.3 A) such that the shorter Ile36 side chain retains the interactions with Ile15 and I33L in PRS17.
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HIV Mutation Detail Information