|
Mutation Information
|
Mutation Site
|
I27L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
E6 |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
NC_001526.2
|
|
Country
|
Mexico |
Literature Information
|
PubMed PMID
|
25889023
|
|
Disease
|
Low grade squamous intraepithelial lesion;
High grade squamous intraepithelial lesion;
Cervical carcinoma;
Squamous-cell carcinoma
|
|
Published Year
|
2015 |
|
Journal
|
Virology journal |
|
Title
|
Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico. |
|
Author
|
Ortiz-Ortiz J,Alarcón-Romero Ldel C,Jiménez-López MA,Garzón-Barrientos VH,Calleja-Macías I,Barrera-Saldaña HA,Leyva-Vázquez MA,Illades-Aguiar B |
|
Evidence
|
According to the HPV variants found in this study, the amino acid substitutions circulating in Southern Mexico are: Q3E, R10G, Q14H, D25N, I27L, I27R I27T, L28V, E29K, E29Q, E29G, I52L, K68T, F69L, H78Y, L83V (the most frequent) and E113D.
|
|
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HPV Mutation Detail Information