|
Mutation Information
|
Mutation Site
|
I268A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
mAb33 |
Literature Information
|
PubMed PMID
|
16790058
|
|
Published Year
|
2006 |
|
Journal
|
Retrovirology |
|
Title
|
Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody. |
|
Author
|
Ramcharan J,Colleluori DM,Merkel G,Andrake MD,Skalka AM |
|
Evidence
|
Two of these derivatives, IN (I276A) and IN (I267A/I268A), exhibited both increased DNA binding affinity and uncharacteristic dissociation kinetics;these proteins also exhibited non-specific nuclease activity.
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HIV Mutation Detail Information