HIV Mutation Detail Information

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Mutation Information
Mutation Site I259V
Mutation Type Amino acid level
Gene/Protein/Region Type IN
Genotype/Subtype CRF63_02A1
Country Russia
Literature Information
PubMed PMID 31024744
Disease HIV infection/AIDS
Published Year 2019
Journal Acta naturae
Title Consensus Integrase of a New HIV-1 Genetic Variant CRF63_02A1.
Author Agapkina YY,Pustovarova MA,Korolev SP,Zyryanova DP,Ivlev VV,Totmenin AV,Gashnikova NM,Gottikh MB
Evidence Preparation of the cDNA encoding IN_CRF and its consecutive cloning allowed us to obtain the pET-15b_IN_CRF* vector, which was then subjected to site-directed mutagenesis to introduce the I32V and I259V substitutions and to obtain the pET-15b_IN_CRF expression vector coding for a consensus IN sequence.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation