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Mutation Information
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Mutation Site
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I224V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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S |
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Viral Reference
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AB776908;
EU410081;
JQ688404 |
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Country
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China |
Literature Information
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PubMed PMID
|
26457811
|
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Disease
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Occult HBV infection
|
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Published Year
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2015 |
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Journal
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PloS one |
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Title
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Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection. |
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Author
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Hu LP,Liu DP,Chen QY,Harrison TJ,He X,Wang XY,Li H,Tan C,Yang QL,Li KW,Fang ZL |
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Evidence
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There are twenty-one amino acid substitutions in the overlapping polymerase in all clones from father’s sample, including F46S, R51K, H55Q, H55R, S57F, P109S, N118T, N124R, Y124H, Q125R, H126Q, 127R, N134D, C136R, N139K, Y141F, S143T, H160R, A211T, S213T and Q215H. Amino acid substitutions in mother include T16I, R41S, V44A,N53S, H55R, W58R, N76D, S81T, V103I, G107E, N121I, I122L, N123D, Q125K, H126Y, N134D, N139H, N139Q, Y158H, I163V, F178L, S185N, V207M, Q215L,Y221F, A222T, I224V, G232R. However, none of these is associated with drug resistance.
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HBV Mutation Detail Information