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Mutation Information
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Mutation Site
|
I203M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
IN |
|
Relevant Drug
|
raltegravir (RAL);etravirine(ETR);darunavir (DRV);ritonavir;elvitegravir (EVG) |
|
Country
|
France |
Literature Information
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PubMed PMID
|
20436677
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2010 |
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Journal
|
PloS one |
|
Title
|
The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions. |
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Author
|
Reigadas S,Anies G,Masquelier B,Calmels C,Stuyver LJ,Parissi V,Fleury H,Andreola ML |
|
Evidence
|
Several polymorphic mutations previously related to INI resistance were present at D0: V72I was present in patients 1 and 3, V151I in patient 2, and I203M in patient 1.
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HIV Mutation Detail Information