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Mutation Information
|
Mutation Site
|
I201V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
CA |
|
Viral Reference
|
AF038399.1
|
|
Relevant Drug
|
PF-46396 |
Literature Information
|
PubMed PMID
|
32272714
|
|
Published Year
|
2020 |
|
Journal
|
Molecules (Basel, Switzerland) |
|
Title
|
Recent Advances in HIV-1 Gag Inhibitor Design and Development. |
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Author
|
Dick A,Cocklin S |
|
Evidence
|
PF-46396 resistance mutations were identified in three regions of Gag: around the CA-SP1 cleavage site similar to BVM but additionally also, at CA amino acid 201 (I201V), and in the CA major homology region (MHR, G156E, P157S, P160L), indicating implications for Gag assembly, release and virus replication
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HIV Mutation Detail Information