|
Mutation Information
|
Mutation Site
|
I195M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
rt.M204V+s.I195M |
|
Genotype/Subtype
|
C |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
24316031
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2014 |
|
Journal
|
Antiviral research |
|
Title
|
Amino acid similarities and divergences in the small surface proteins of genotype C hepatitis B viruses between nucleos(t)ide analogue-naïve and lamivudine-treated patients with chronic hepatitis B. |
|
Author
|
Ding H,Liu B,Zhao C,Yang J,Yan C,Yan L,Zhuang H,Li T |
|
Evidence
|
With little influence on immune escape-associated mutation frequencies within 'a' determinant, LMV-monotherapy significantly induced classical LMVr-associated mirror changes sE164D/rtV173L, sI195M/rtM204V and sW196L/S/rtM204I, as well as non-classical ones sG44E/rtS53N, sT47K/A/rtH55R/Q and sW182stop/rtV191I outside 'a' determinant.
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HBV Mutation Detail Information