|
Mutation Information
|
Mutation Site
|
I195M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.E164D+s.I195M |
|
Genotype/Subtype
|
A;D |
|
Immune Escape
|
Y |
|
Country
|
Italy+other countries |
Literature Information
|
PubMed PMID
|
19041149
|
|
Disease
|
HBV infection
|
|
Published Year
|
2009 |
|
Journal
|
Journal of hepatology |
|
Title
|
The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes. |
|
Author
|
Svicher V,Gori C,Trignetti M,Visca M,Micheli V,Bernassola M,Salpini R,Gubertini G,Longo R,Niero F,Ceccherini-Silberstein F,De Sanctis GM,Spanò A,Cappiello G,Perno CF |
|
Evidence
|
Among the immune escape mutations associated with LMV treatment, the pairs sI195M+sE164D (corresponding to rtM204V+rtV173L), known to drastically reduce HBsAg antigenicity [13], was observed in 4.7% and 9.1% of patients infected with genotypes D and A, respectively.
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HBV Mutation Detail Information