Mutation Information
Mutation Site
|
I195M |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
S |
Relevant Drug
|
lamivudine (LAM) |
Literature Information
PubMed PMID
|
16928212
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2006 |
Journal
|
Journal of gastroenterology and hepatology |
Title
|
Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy. |
Author
|
Kazim SN,Chauhan R,Das BC,Sarin SK |
Evidence
|
Well known lamivudine resistant rtYM204I/VDD mutations resulted in three types of mutations in the overlapping portions of the HBsAg encoded by S‐gene, that is, I195M (Fig.2d), W196L (Fig.2e) and W196Stop (Fig.2b) in these patients.
|
|
|