HIV Mutation Detail Information

> I194A Search Result

Mutation Information

Mutation Site	I194A
Mutation Type	Amino acid level
Gene/Protein/Region Type	Env
Viral Reference	K03455.1

Literature Information

PubMed PMID	33785631
Published Year	2021
Journal	mBio
Title	Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State.
Author	Zhang P,Kwon AL,Guzzo C,Liu Q,Schmeisser H,Miao H,Lin Y,Cimbro R,Huang J,Connors M,Schmidt SD,Dolan MA,Armstrong AA,Lusso P
Evidence	All the alanine substitutions were predicted to have destabilizing effects, albeit to various extents, with the exception of I194A, which in all three backgrounds was predicted to be neutral, and V134A in the JR-FL background, which had a borderline calculated DeltaDeltaG of 0.96, near the threshold of 1.0 above which mutations were classified as destabilizing.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation