HIV Mutation Detail Information

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Mutation Information

Mutation Site	I17T
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vpu
Country	USA

Literature Information

PubMed PMID	24465210
Disease	HIV infection/AIDS
Published Year	2014
Journal	PLoS pathogens
Title	Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals.
Author	Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ
Evidence	However, of the three in which specific changes could be assigned to loss of function, these mapped to conserved residues in the first alpha helix of the Vpu cytoplasmic tail (n = 1) and transmembrane region (n = 2), specifically I17T, V22A and I39L.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation