|
Mutation Information
|
Mutation Site
|
I15V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
PR |
|
Relevant Drug
|
lopinavir(LPV);ritonavir |
|
Country
|
UK |
Literature Information
|
PubMed PMID
|
22110581
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2011 |
|
Journal
|
PloS one |
|
Title
|
Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score. |
|
Author
|
Cozzi-Lepri A,Prosperi MC,Kjær J,Dunn D,Paredes R,Sabin CA,Lundgren JD,Phillips AN,Pillay D,EuroSIDA Study.,United Kingdom CHIC/United Kingdom HDRD Study. |
|
Evidence
|
Our analysis identified mutations V82A, I54V, K20I and I62V, which were associated with reduced viral response and mutations I15V and V91S which determined lopinavir/r hypersensitivity.
|
|
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HIV Mutation Detail Information