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Mutation Information
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Mutation Site
|
I154A |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Gp120 |
|
Country
|
America |
Literature Information
|
PubMed PMID
|
25174000
|
|
Published Year
|
2014 |
|
Journal
|
Nature chemical biology |
|
Title
|
A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. |
|
Author
|
Herschhorn A,Gu C,Espy N,Richard J,Finzi A,Sodroski JG |
|
Evidence
|
Preincubation with sCD4 reduced PG9 binding to most of the Env mutants and this effect was significantly enhanced for the I154A, N156A, L193A and M434A mutants relative to the wild-type Env.
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HIV Mutation Detail Information