HIV Mutation Detail Information

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Mutation Information

Mutation Site	I142V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	NRTIs

Literature Information

PubMed PMID	30174310
Published Year	2018
Journal	Cell chemical biology
Title	The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase.
Author	Takamatsu Y,Das D,Kohgo S,Hayashi H,Delino NS,Sarafianos SG,Mitsuya H,Maeda K
Evidence	Kawamoto et al. reported that a moderate resistance of HIV-1 against EFdA (22-fold change compared with that against wild-type HIV-1 [HIV-1WT]) was associated with three amino acid substitutions (I142V, T165R, and M184V) in the RT-encoding gene (Kawamoto et al., 2008).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation