|
Mutation Information
|
Mutation Site
|
I127T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
X |
|
Combined Mutation
|
x.V131I+x.K130M+x.I127T+bcp.G1764A+bcp.A1762T+bcp.T1753C |
|
Amino acid_Mutation
|
T1753C |
|
Genotype/Subtype
|
D |
|
Country
|
Irish |
Literature Information
|
PubMed PMID
|
18649329
|
|
Disease
|
Acute hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Journal of medical virology |
|
Title
|
Molecular characterization of hepatitis B virus (HBV) isolates, including identification of a novel recombinant, in patients with acute HBV infection attending an Irish hospital. |
|
Author
|
Laoi BN,Crowley B |
|
Evidence
|
Because the BCP region encompasses nucleotides 1,742–1,802 and overlaps the X gene in the concomitant reading frame, the triple mutation,T1753C/A1762T/G1764A identified in Irish-3, caused changes in the X protein at amino acids I127T, K130M,and V131I.
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HBV Mutation Detail Information