HBV Mutation Detail Information

> I126T Search Result


Mutation Information
Mutation Site I126T
Mutation Type Amino acid level
Gene/Protein/Region Type S
Genotype/Subtype C
Viral Reference GQ184326C; GQ377642; DQ478901; EF688062; AB033556; EU439009; EU562219; AB298721; EU560441
Country Philippines
Literature Information
PubMed PMID 24009186
Disease Chronic hepatitis B
Published Year 2014
Journal Journal of medical virology
Title Unique surface gene variants of hepatitis B virus isolated from patients in the Philippines.
Author Baclig MO,Alvarez MR,Gopez-Cervantes J,Natividad FF
Evidence Out of the 23 isolates, 15 (65%) exhibited single or multiple substitutions, which resulted to specific amino acid changes as follows: Tyrosine (Y) to Cysteine (C) at position 100, Glutamine (Q) to Lysine (K) at position 101, Glycine (G) to Serine (S) at position 102, Methionine (M) to Isoleucine (I) at position 103, Leucine (L) to Proline (P) at position 109, Isoleucine (I) to Leucine (L) at position 110, Leucine (L) to Isoleucine (I) at position 110, Threonine (T) to Serine (S) at position 113, Threonine (T) to Asparagine (N) at position 116, Serine (S) to Arginine (R) at position 117, Isoluecine (I) to Threonine (T) at position 126, Isoleucine (I) to Serine (S) at position 126, Proline (P) to Threonine (T) at position 127, Glycine (G) to Serine (S) at position 130, Methionine (M) to Threonine (T) at position 133, Phenylalanine (F) to Isoleucine (I) at position 134, Serine (S) to Leucine (L) at position 136, and Aspartic acid (D) to Alanine (A) at position 144 as shown in Figures 1-3.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation