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Mutation Information
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Mutation Site
|
I124V |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
LMP1 |
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Viral Reference
|
V01555.2
|
|
Country
|
Swiss |
Literature Information
|
PubMed PMID
|
22384168
|
|
Disease
|
B-cell lymphoma;
T-cell lymphoma;
Hodgkin lymphoma
|
|
Published Year
|
2012 |
|
Journal
|
PloS one |
|
Title
|
Genetic diversity of EBV-encoded LMP1 in the Swiss HIV Cohort Study and implication for NF-Κb activation. |
|
Author
|
Zuercher E,Butticaz C,Wyniger J,Martinez R,Battegay M,Boffi El Amari E,Dang T,Egger JF,Fehr J,Mueller-Garamvögyi E,Parini A,Schaefer SC,Schoeni-Affolter F,Thurnheer C,Tinguely M,Telenti A,Rothenberger S,Swiss HIV Cohort Study. |
|
Evidence
|
The two polymorphisms I124V and F144I were present in distinct phylogenetic groups and were linked with other specific polymorphisms nearby, I152L and D150A/L151I, respectively. The two sets of polymorphisms, I124V/I152L and F144I/D150A/L151I, which were markers of increased NF-kappaB activation in vitro, were not associated with EBV-associated HL in the SHCS.
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EBV Mutation Detail Information