HBV Mutation Detail Information

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Mutation Information

Mutation Site	I116L
Mutation Type	Amino acid level
Gene/Protein/Region Type	C
Amino acid_Mutation	A2246C
Genotype/Subtype	D
Country	India

Literature Information

PubMed PMID	25333524
Disease	Hepatocellular carcinoma; Liver cirrhosis
Published Year	2014
Journal	PloS one
Title	Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Author	Datta S,Ghosh A,Dasgupta D,Ghosh A,Roychoudhury S,Roy G,Das S,Das K,Gupta S,Basu K,Basu A,Datta S,Chowdhury A,Banerjee S
Evidence	Beyond the classical mutations in basal core promoter (BCP) (A1762T/G1764A) and precore (G1862T), persistence of progressively accumulated mutations in enhancer-I, surface, HBx and core were showed significant association to liver disease progression. BCP_T1753C, core_T147C, surface_L213I had contributed significantly in the disease progression to HCC (p<0.05) in HBeAg positive patients whereas precore_T1858C, core_I116L, core_P130Q and preS1_S98T in HBeAg negative patients.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation