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Mutation Information
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Mutation Site
|
I114V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Nef |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
K03455.1
|
|
Country
|
Boston (USA) |
Literature Information
|
PubMed PMID
|
31693887
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2019 |
|
Journal
|
Cell reports |
|
Title
|
Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity. |
|
Author
|
Jin SW,Alsahafi N,Kuang XT,Swann SA,Toyoda M,Göttlinger H,Walker BD,Ueno T,Finzi A,Brumme ZL,Brockman MA |
|
Evidence
|
Specifically, downregulation function was increased modestly for N51T, I114V, and S163C mutants, each of which displayed ~5% higher activity compared with parental Nef;whereas downregulation was impaired for C55S, K94E, H116N, V148L, and S163R mutants, each of which displayed 5%-50% lower activity compared with parental Nef.
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HIV Mutation Detail Information