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Mutation Information
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Mutation Site
|
I110L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Relevant Drug
|
hepatitis B immunoglobulin (HBIG) |
|
Country
|
Turkey |
Literature Information
|
PubMed PMID
|
31130119
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2019 |
|
Journal
|
Mikrobiyoloji bulteni |
|
Title
|
[HBV pol/S gene mutations in chronic hepatitis B patients receiving nucleoside/nucleotide analogues treatment]. |
|
Author
|
Kırdar S,Yaşa MH,Sayan M,Aydın N |
|
Evidence
|
Because of the HBV pol/S gene overlapping, in 27 patients immun-selected amino acid substitutions (sI110L, sT127P, sS114A, sT123A), in nine patients HBIg selected escape mutants (sP120R, sT123N, sE164D, sY134F, sQ129H, sT118A, sP127K), in seven patients vaccine escape mutants (sT126I, sP120S, sG145A, s S193L) and in one patient misdiagnosis of HBsAg (sT131I) were detected.
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HBV Mutation Detail Information