HBV Mutation Detail Information

> I105T Search Result

Mutation Information

Mutation Site	I105T
Mutation Type	Amino acid level
Gene/Protein/Region Type	C
Genotype/Subtype	A
Viral Reference	X02763
Country	Asia‐Pacific;Europe

Literature Information

PubMed PMID	32579776
Disease	Chronic hepatitis B
Published Year	2020
Journal	Journal of viral hepatitis
Title	Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.
Author	Verbinnen T,Hodari M,Talloen W,Berke JM,Blue D,Yogaratnam J,Vandenbossche J,Shukla U,De Meyer S,Lenz O
Evidence	Two 250 mg JNJ‐6379‐treated patients had baseline I105T polymorphism, not conferring in vitro resistance to JNJ‐6379 (FC = 2.7) but described to reduce AB‐506 (CAM‐N) in vitro activity by 19‐fold and leading to lack of response to AB‐506 treatment in a phase 1 study.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation