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Mutation Information
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Mutation Site
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I105T |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
C |
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Genotype/Subtype
|
B |
Literature Information
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PubMed PMID
|
26598693
|
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Published Year
|
2015 |
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Journal
|
Proceedings of the National Academy of Sciences of the United States of America |
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Title
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High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. |
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Author
|
Klumpp K,Lam AM,Lukacs C,Vogel R,Ren S,Espiritu C,Baydo R,Atkins K,Abendroth J,Liao G,Efimov A,Hartman G,Flores OA |
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Evidence
|
The replication competence of these polymorphisms was evaluated using a transient transfection phenotyping assay based on a total of nine different core variants generated in the context of the HBV genotype B strain: W102G, W102R, I105L, I105T, I105V, T109I, T109M, T109S, and Y118F.
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HBV Mutation Detail Information